Synthesis of tetrahydronaphthyl thioureas as potent appetite suppressants.
نویسندگان
چکیده
A series of thiourea derivatives (7-23, 25-27) of 1-aminotetrahydronaphthalene (4) and 1-amino-2-hydroxytetrahydronaphthalene (5) were synthesized in single pot in 48-90% yield and evaluated for their anorexigenic activity. Among them compounds 10, 14, 15, 16 and 22 exhibited significant anorexigenic activity without any antidepressant effect and provided a new structural lead for appetite suppressants.
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry
دوره 12 15 شماره
صفحات -
تاریخ انتشار 2004